Emergence of resistant Klebsiella pneumoniae in the intestinal tract during a 1 successful treatment of Klebsiella pneumoniae lung infection in rats
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چکیده
Emergence of resistant Klebsiella pneumoniae in the intestinal tract during a 1 successful treatment of Klebsiella pneumoniae lung infection in rats. 2 3 Running Title: Intestinal Impact of Fluoroquinolones 4 5 6 Anne-Sylvie Kesteman, Agnès Perrin-Guyomard, Michel Laurentie, Pascal Sanders, 7 Pierre-Louis Toutain and Alain Bousquet-Mélou 8 9 1 UMR181 Physiopathologie et Toxicologie Expérimentales, INRA, ENVT, Ecole Nationale 10 Vétérinaire de Toulouse, 23 chemin des Capelles, BP 87614, 31076 Toulouse Cedex 3, 11 France. 12 13 2 Laboratory for the Research and Investigation of Veterinary Drugs and Disinfectants, 14 AFSSA Fougères, La Haute Marche, BP 90203, Javené 35302 Fougères, France 15 16 Potential conflicts of interest: none 17 Financial support: grant from the Institut National de la Recherche Agronomique (INRA) and 18 from the Agence Française de Sécurité Sanitaire des Aliments (AFSSA). 19 Corresponding author: Prof. Alain Bousquet-Mélou, Mailing address: UMR181 20 Physiopathologie et Toxicologie Expérimentales, INRA, ENVT, Ecole Nationale Vétérinaire 21 de Toulouse, 23 chemin des Capelles, BP 87 614, 31076 Toulouse Cedex 3, France. Phone: 22 +33 (0)5.61.19.39.25. Fax: +33 (0)5.61.19.39.17. E-mail: [email protected]. 23 24 Abstract: 196 words 25 Text: 3008 words 26 Copyright © 2010, American Society for Microbiology and/or the Listed Authors/Institutions. All Rights Reserved. Antimicrob. Agents Chemother. doi:10.1128/AAC.01612-09 AAC Accepts, published online ahead of print on 10 May 2010
منابع مشابه
Emergence of resistant Klebsiella pneumoniae in the intestinal tract during successful treatment of Klebsiella pneumoniae lung infection in rats.
Antibiotic treatment of lung infections may lead to the emergence of resistance in the gut flora. Appropriate dosing regimens could mitigate this adverse effect. In gnotobiotic rats harboring intestinal Escherichia coli and Enterococcus faecium populations, a lung infection by Klebsiella pneumoniae was instigated with two different sizes of inoculum to represent an early or a late initiation of...
متن کاملEmergence of resistant Klebsiella pneumoniae in the intestinal tract during a 1 successful treatment of Klebsiella pneumoniae lung infection in rats . 2 3 Running Title : Intestinal Impact of Fluoroquinolones 4 5 6
Emergence of resistant Klebsiella pneumoniae in the intestinal tract during a 1 successful treatment of Klebsiella pneumoniae lung infection in rats. 2 3 Running Title: Intestinal Impact of Fluoroquinolones 4 5 6 Anne-Sylvie Kesteman, Agnès Perrin-Guyomard, Michel Laurentie, Pascal Sanders, 7 Pierre-Louis Toutain and Alain Bousquet-Mélou 8 9 1 UMR181 Physiopathologie et Toxicologie Expérimental...
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Background: The urinary tract infection is the secondary most common human infection. Colon bacteria, including Klebsiella pneumonia, are the main cause of urinary tract infections. The occurrence of the antibiotic resistance is a major problem in the treatment of infections. Beta- lactamases and efflux pumps constitute the major defense mechanisms of antibiotic resistance of Klebsiella pneumon...
متن کاملThe Prevalence of Carbapenemase Producing Klebsiella pneumoniae Strains Isolated from Clinical Urine Specimens in University Teaching Hospitals, Iran
Background and Aims: Klebsiella pneumoniae is a gram negative opportunistic pathogen of nosocomial infections that causes pneumonia, urinary tract infection (UTI), meningitis, septicemia and diarrhea. The emergence and spread of carbapenemase producing Klebsiella pneumoniae often cause failure in the treatment of infections. The aim of this study was to evaluate the prevalence of carbapenemase ...
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Background and Objectives: Urinary tract infection (UTI) is the presence of pathogens in the urinary tract. Escherichia coli and Klebsiella pneumoniae are the most common bacteria responsible for UTI. Due to the variety of antibiotic resistance mechanisms, treatment of these infections has been difficult, therefore, selection of appropriate antibiotic has an effective role in controlling and im...
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تاریخ انتشار 2010