Emergence of resistant Klebsiella pneumoniae in the intestinal tract during a 1 successful treatment of Klebsiella pneumoniae lung infection in rats

Emergence of resistant Klebsiella pneumoniae in the intestinal tract during a 1 successful treatment of Klebsiella pneumoniae lung infection in rats. 2 3 Running Title: Intestinal Impact of Fluoroquinolones 4 5 6 Anne-Sylvie Kesteman, Agnès Perrin-Guyomard, Michel Laurentie, Pascal Sanders, 7 Pierre-Louis Toutain and Alain Bousquet-Mélou 8 9 1 UMR181 Physiopathologie et Toxicologie Expérimentales, INRA, ENVT, Ecole Nationale 10 Vétérinaire de Toulouse, 23 chemin des Capelles, BP 87614, 31076 Toulouse Cedex 3, 11 France. 12 13 2 Laboratory for the Research and Investigation of Veterinary Drugs and Disinfectants, 14 AFSSA Fougères, La Haute Marche, BP 90203, Javené 35302 Fougères, France 15 16 Potential conflicts of interest: none 17 Financial support: grant from the Institut National de la Recherche Agronomique (INRA) and 18 from the Agence Française de Sécurité Sanitaire des Aliments (AFSSA). 19 Corresponding author: Prof. Alain Bousquet-Mélou, Mailing address: UMR181 20 Physiopathologie et Toxicologie Expérimentales, INRA, ENVT, Ecole Nationale Vétérinaire 21 de Toulouse, 23 chemin des Capelles, BP 87 614, 31076 Toulouse Cedex 3, France. Phone: 22 +33 (0)5.61.19.39.25. Fax: +33 (0)5.61.19.39.17. E-mail: [email protected]. 23 24 Abstract: 196 words 25 Text: 3008 words 26 Copyright © 2010, American Society for Microbiology and/or the Listed Authors/Institutions. All Rights Reserved. Antimicrob. Agents Chemother. doi:10.1128/AAC.01612-09 AAC Accepts, published online ahead of print on 10 May 2010